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Pediatric HSCT recipients (n = 16)
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Healthy controls (n = 16)
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P value
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|---|
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LV mass and dimensions
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Mass, g
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95 ± 18
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108 ± 23
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0.078
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Mass/BSA, g/m2
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53 ± 9
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57 ± 10
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0.328
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End-diastolic volume, mL
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155 ± 29
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176 ± 30
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0.052
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End-diastolic volume/BSA, mL/m2
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87 ± 14
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93 ± 13
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0.238
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Mass/end-diastolic volume, g/mL
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0.62 ± 0.10
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0.61 ± 0.08
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0.867
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LV systolic function
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Stroke volume, mL
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83 ± 15
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101 ± 17
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0.003*
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Cardiac output, L
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5.2 ± 1.0
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6.5 ± 1.0
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0.001*
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Cardiac index, L/m2
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2.9 ± 0.6
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3.4 ± 0.5
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0.021*
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Ejection fraction, %
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54 ± 6
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58 ± 5
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0.055
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Global longitudinal strain, %
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−20.7 ± 3.5
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−22.9 ± 3.0
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0.063
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Global circumferential strain, %
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−23.2 ± 3.6
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−23.9 ± 3.5
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0.587
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Longitudinal peak systolic strain rate, 1/s
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−0.95 ± 0.20
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−1.06 ± 0.21
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0.137
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Circumferential peak systolic strain rate, 1/s
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−1.21 ± 0.22
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−1.32 ± 0.36
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0.216
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LV diastolic function
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E/A ratio
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2.76 ± 0.92
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2.97 ± 0.91
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0.599‡
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Estimated LV filling pressure
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9.92 ± 3.42
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7.24 ± 2.29
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0.004‡
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Longitudinal early diastolic strain rate, 1/s
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1.01 ± 0.26
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1.15 ± 0.35
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0.224
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Circumferential early diastolic strain rate, 1/s
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1.28 ± 0.29
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1.38 ± 0.35
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0.396
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LV myocardial tissue characteristics
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Myocardial triglyceride content, %
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0.47 ± 0.18
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0.50 ± 0.13
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0.202‡
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Native T1 relaxation time, ms
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1211 ± 36
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1227 ± 28
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0.158
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Aortic stiffness
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Aortic pulse wave velocity, m/s
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4.40 ± 0.26
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4.29 ± 0.29
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0.288
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- Values are presented as means ± standard deviations. *P < 0.05. ‡P value not based on the Student’s t-test but on the Mann-Whitney U test. HSCT hematopoietic stem cell transplantation, LV left ventricle, BSA body surface area, E/A ratio ratio of early and late peak filling rate. Estimated LV filling pressure: ratio of transmitral early peak velocity and early diastolic mitral septal tissue velocity (E/Ea)
