Cardiovascular magnetic resonance based diagnosis of left ventricular non-compaction cardiomyopathy: impact of cine bSSFP strain analysis

Table 2 CMR Diagnostic Criteria for LVNC

	All patients and healthy subjects			Subgroup A	Subgroup B	Subgroup C	Subgroup D	A vs. B	A vs. C	A vs. D	C vs. D
	All LVNC phenotype patients	All healthy subjects	p-values	LVNC phenotype patients (normal LV volumetrics)	Healthy subjects (normal LV volumetrics)	Healthy subjects (normal LV volumetrics, not meeting any LVNC criteria)	Healthy subjects (normal LV volumetrics, meeting one or more LVNC criteria)	p-values	p-values	p-values	p-values
	(n = 59)	(n = 36)		(n = 25)	(n = 34)	(n = 16)	(n = 18)
Number of NC segments^b	8 (6, 9)	0 (0, 0)	< 0.001	8 (6, 9)	0 (0, 0)	0 (0, 0)	0 (0, 1)	< 0.001	< 0.001	< 0.001	0.013
Maximum NC:C ratio^b	3.8 (3.0, 4.3)	1.2 (0.9, 1.6)	< 0.001	3.5 (3.2, 4.3)	1.1 (0.9, 1.3)	1.0 (0.8, 1.2)	1.2 (0.9, 2.5)	< 0.001	< 0.001	< 0.001	0.182
NC:C > 2.3^a	59 (100%)	7 (19.4%)	< 0.001	25 (100%)	6 (17.7%)	0 (0%)	6 (33.3%)	< 0.001	< 0.001	< 0.001	0.020
Percentage of NC mass (%)^b	40.8 (35.7, 45.9)	19.5 (17.2, 23.3)	< 0.001	42.2 (38.7, 47.1)	19.3 (17.1, 23.6)	17.2 (14.8, 18.5)	23.3 (20.1, 30.7)	< 0.001	< 0.001	< 0.001	< 0.001
NC mass > 20%^a	59 (100%)	16 (44.4%)	< 0.001	25 (100%)	14 (41.2%)	0 (0%)	14 (77.8%)	< 0.001	< 0.001	0.025	< 0.001
NC mass > 25%^a	59 (100%)	5 (13.9%)	< 0.001	25 (100%)	5 (14.7%)	0 (0%)	5 (27.8%)	< 0.001	< 0.001	< 0.001	0.046
NC mass/BSA (g/m²)^b	36.1 (32.3, 42.9)	13.6 (10.5, 17.2)	< 0.001	35.1 (30.9, 39.2)	12.7 (10.4, 17.0)	10.0 (8.8, 11.6)	17.0 (15.0, 23.7)	< 0.001	< 0.001	< 0.001	< 0.001
NC mass > 15 g/m^2a	59 (100%)	15 (41.7%)	< 0.001	25 (100%)	13 (38.2%)	0 (0%)	13 (72.2%)	< 0.001	< 0.001	0.009	< 0.001

Data presented as n (%) or median (IQR)
NC:C >2.3 = maximum end-diastolic non-compacted (NC): compacted (C) myocardium diameter ratio >2.3 in at least one segment.
CMR cardiovascular magnetic resonance, LVNC left ventricular non-compaction cardiomyopathy, LV left ventricle, NC non-compacted myocardium, C compacted myocardium, BSA body surface area
^aFisher’s exact test
^bWilcoxon rank sum test

ISSN: 1532-429X